Autotaxin: inhibiting a greasy pocket Medicinal significance of autotaxin
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چکیده
Autotaxin (ATX) is a secreted glycoprotein that has been implicated in various physiological and pathophysiological processes, including vascular and neural development, lymphocyte trafficking, fibrosis and tumour progression. ATX functions as lysophopholipase D (lysoPLD), hydrolysing lysophosphatidylcholine (LPC) into the signalling lipid lysophosphatidic acid (LPA). LPA stimulates cell migration, proliferation and survival in many cell types by binding to specific G protein-coupled receptors (GPCRs). Given its emerging role in disease, ATX is actively pursued as a drug target in both academia and industry.
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